Paracrine signaling

Across TCGA cell cohorts, RNA activity of the Paracrine signaling pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RGS19, SDR42E1, and CDK11B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RGS19 grouped by Paracrine signaling-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	RGS19 →	-0.232	-1.091	.005	.005	3	4
LUNG_SCLC	SDR42E1 →	+0.222	+1.156	.008	.005	3	4
LUNG_NSCLC_LUSC	CDK11B →	-0.424	-1.502	.003	.002	3	4
UPPER_AERODIGESTIVE_TRACT	PPP1R12A →	+0.343	+0.151	.005	.002	3	4
BONE	RBPJL →	-0.150	-1.102	.002	.005	3	4
BONE	ACLY →	-0.277	-1.369	.006	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RGS19 by Paracrine signaling activity — LUNG_SCLC

Explore this box plot interactively →