Paracrine signaling

Across TCGA cell cohorts, RNA activity of the Paracrine signaling pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF438, KCNQ4, and KRT13, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Paracrine signaling activity versus ZNF438 in URINARY_TRACT (Pearson r = -0.93).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	ZNF438 →	-1.223	-1.562	.004	<.001	3	4
PANCREAS	KCNQ4 →	+1.743	+1.700	.007	<.001	3	3
PANCREAS	KRT13 →	+2.571	+1.700	.004	<.001	3	3
URINARY_TRACT	PTGS2 →	+4.246	+1.562	<.001	<.001	3	3
URINARY_TRACT	LPAR2 →	+1.650	+1.562	.001	<.001	3	3
OESOPHAGUS	PDE6D →	-0.826	-1.838	.003	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0038001 vs ZNF438 — URINARY_TRACT

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