ERAD pathway

Across TCGA patient cohorts, RNA activity of the ERAD pathway pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are EEF2_S502, MAP2_S862, and C8orf37_S96, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, ERAD pathway activity versus EEF2_S502 in CCRCC (Pearson r = -0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	EEF2_S502 →	-0.619	-0.032	.002	<.001	3	5
LUAD	MAP2_S862 →	+0.926	+0.028	<.001	<.001	3	5
LUAD	C8orf37_S96 →	+0.588	+0.033	.001	<.001	3	5
GBM	ARHGAP12_S240 →	-0.440	-0.051	.004	<.001	3	5
CCRCC	PALM →	+0.281	+0.017	.005	.009	3	5
LUAD	MAP1A_S2106 →	+0.416	+0.023	.008	.007	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036503 vs EEF2_S502 — CCRCC

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