ERAD pathway

Across TCGA cell cohorts, RNA activity of the ERAD pathway pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are H2BS1, RAB27A, and GMEB2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, ERAD pathway activity versus H2BS1 in BLOOD_Lymphoma (Pearson r = 0.37).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	H2BS1 →	+0.898	+0.092	.004	.008	3	5
BLOOD_Lymphoma	RAB27A →	+1.422	+0.094	.009	.007	3	5
LUNG_SCLC	GMEB2 →	-0.434	-0.104	.004	.007	3	4
LUNG_SCLC	CSRNP1 →	+1.360	+0.147	<.001	.001	3	4
LUNG_SCLC	TENT5B →	+1.678	+0.141	.001	.003	3	4
LUNG_SCLC	CTSO →	+1.329	+0.108	<.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036503 vs H2BS1 — BLOOD_Lymphoma

Explore this scatter interactively →