PERK-mediated unfolded protein response

Across TCGA cell cohorts, RNA activity of the PERK-mediated unfolded protein response pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KLHL24, PREP, and CARHSP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, PERK-mediated unfolded protein response activity versus KLHL24 in LUNG_SCLC (Pearson r = -0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	KLHL24 →	-1.205	-0.232	.002	.002	3	5
OESOPHAGUS	PREP →	+1.190	+0.335	<.001	<.001	3	4
BLOOD_Leukemia	CARHSP1 →	-1.238	-0.199	<.001	<.001	3	4
BLOOD_Leukemia	RIN3 →	+1.733	+0.202	<.001	.001	3	4
BLOOD_Leukemia	MED31 →	-0.690	-0.232	<.001	.001	3	4
BLOOD_Lymphoma	ALDH5A1 →	-2.985	-0.253	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036499 vs KLHL24 — LUNG_SCLC

Explore this scatter interactively →