IRE1-mediated unfolded protein response

Across TCGA patient cohorts, RNA activity of the IRE1-mediated unfolded protein response pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SSRP1_S672, DLC1_S544, and AKAP13_S2563, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, IRE1-mediated unfolded protein response activity versus SSRP1_S672 in OV (Pearson r = -0.01).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SSRP1_S672 →	-0.850	-0.047	.004	.005	3	5
PDAC	DLC1_S544 →	+0.598	+0.034	.001	<.001	3	5
LSCC	AKAP13_S2563 →	+0.464	+0.034	<.001	<.001	3	5
PDAC	AKAP8_S328 →	-0.763	-0.054	<.001	<.001	3	5
LSCC	ANK2_S3909 →	+1.147	+0.045	.001	.004	3	5
GBM	MYLK →	+0.492	+0.039	.007	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036498 vs SSRP1_S672 — OV

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