IRE1-mediated unfolded protein response

Across TCGA patient cohorts, RNA activity of the IRE1-mediated unfolded protein response pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPL28P2, ZNF740, and ZNF251, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, IRE1-mediated unfolded protein response activity versus RPL28P2 in CCRCC (Pearson r = -0.13).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	RPL28P2 →	-0.353	-0.180	<.001	<.001	3	4
UCEC	ZNF740 →	-0.516	-0.162	<.001	<.001	3	4
PDAC	ZNF251 →	-0.346	-0.358	<.001	.001	3	4
PDAC	LINC02006 →	-0.185	-0.382	.009	.006	3	4
COAD	LMBR1L →	-0.324	-0.066	<.001	.009	3	3
BRCA	RBP4 →	-1.797	-0.127	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036498 vs RPL28P2 — CCRCC

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