IRE1-mediated unfolded protein response

Across TCGA cell cohorts, RNA activity of the IRE1-mediated unfolded protein response pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PTPN1, ACSL4, and ZNF878, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, IRE1-mediated unfolded protein response activity versus PTPN1 in OESOPHAGUS (Pearson r = 0.60).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	PTPN1 →	+0.945	+0.151	<.001	<.001	3	6
OESOPHAGUS	ACSL4 →	+1.183	+0.144	.001	<.001	3	5
BLOOD_Myeloma	ZNF878 →	+0.425	+0.197	<.001	<.001	3	5
LUNG_NSCLC_LUSC	SNTA1 →	+2.027	+0.204	<.001	.002	3	5
OESOPHAGUS	RTF2 →	+0.526	+0.129	.007	.004	2	5
BREAST	MYL9 →	+3.199	+0.135	.003	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036498 vs PTPN1 — OESOPHAGUS

Explore this scatter interactively →