Positive regulation of translation in response to endoplasmic reticulum stress

Across TCGA patient cohorts, RNA activity of the Positive regulation of translation in response to endoplasmic reticulum stress pathway is significantly associated with the RNA expression of multiple genes, with the DLBC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are STAG1, PIK3CA, and ZBTB1, each associated with the pathway in up to 33 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of translation in response to endoplasmic reticulum stress activity versus STAG1 in DLBC (Pearson r = 0.65).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
DLBC	STAG1 →	+1.556	+0.101	<.001	<.001	3	33
KICH	PIK3CA →	+1.540	+0.075	<.001	<.001	3	33
UVM	ZBTB1 →	+1.660	+0.066	<.001	<.001	3	33
UVM	DNAJC13 →	+1.646	+0.053	<.001	<.001	3	33
UVM	SCAF11 →	+1.490	+0.068	<.001	<.001	3	33
DLBC	NCK1 →	+1.388	+0.098	<.001	<.001	3	33

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036493 vs STAG1 — DLBC

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