Positive regulation of translation in response to endoplasmic reticulum stress

Across TCGA patient cohorts, RNA activity of the Positive regulation of translation in response to endoplasmic reticulum stress pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NCK1, ACAP2, and DNAJC13, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of translation in response to endoplasmic reticulum stress activity versus NCK1 in BRCA (Pearson r = 0.38).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	NCK1 →	+0.391	+0.055	<.001	<.001	3	10
HNSC	ACAP2 →	+0.300	+0.065	.008	.008	2	8
OV	DNAJC13 →	+0.189	+0.052	<.001	.005	3	7
BRCA	STRBP →	-0.384	-0.037	.005	.003	3	6
BRCA	TRIM38 →	+0.239	+0.033	<.001	<.001	3	6
GBM	AIF1 →	+0.794	+0.042	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036493 vs NCK1 — BRCA

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