Positive regulation of translation in response to endoplasmic reticulum stress

Across TCGA patient cohorts, RNA activity of the Positive regulation of translation in response to endoplasmic reticulum stress pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KHDRBS2, SUSD5, and RASSF1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of translation in response to endoplasmic reticulum stress activity versus KHDRBS2 in PDAC (Pearson r = -0.40).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	KHDRBS2 →	-0.341	-0.222	.001	.006	3	4
HNSC	SUSD5 →	-0.495	-0.116	.003	.001	3	4
LSCC	RASSF1 →	-0.314	-0.568	.001	.001	3	4
GBM	LHX6 →	-0.450	-0.257	.005	.005	3	3
GBM	SH3GL2 →	-1.219	-0.212	.005	.006	3	3
GBM	HPCAL4 →	-1.329	-0.288	.003	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036493 vs KHDRBS2 — PDAC

Explore this scatter interactively →