Regulation of translation initiation in response to endoplasmic reticulum stress

Across TCGA patient cohorts, RNA activity of the Regulation of translation initiation in response to endoplasmic reticulum stress pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are LRPPRC, STAB1, and WIPF1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of translation initiation in response to endoplasmic reticulum stress activity versus LRPPRC in COAD (Pearson r = -0.28).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	LRPPRC →	-0.356	-0.040	<.001	<.001	3	8
UCEC	STAB1 →	+0.318	+0.054	<.001	.008	3	7
UCEC	WIPF1 →	+0.334	+0.075	.003	.003	3	7
LSCC	MRPS23 →	-0.376	-0.045	.002	.005	3	7
OV	MRPS9 →	-0.339	-0.070	<.001	<.001	3	7
COAD	MRPS31 →	-0.407	-0.040	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036491 vs LRPPRC — COAD

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