Regulation of translation initiation in response to endoplasmic reticulum stress

Across TCGA patient cohorts, RNA activity of the Regulation of translation initiation in response to endoplasmic reticulum stress pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RN7SL592P, PLIN2, and PRDX5, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of translation initiation in response to endoplasmic reticulum stress activity versus RN7SL592P in CCRCC (Pearson r = -0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	RN7SL592P →	-0.358	-0.435	<.001	<.001	3	3
HNSC	PLIN2 →	-0.824	-0.457	.001	<.001	3	3
LUAD	PRDX5 →	-0.337	-0.430	.009	.007	3	3
GBM	HIVEP2 →	-0.430	-0.790	<.001	.001	3	2
GBM	XPNPEP2 →	-0.299	-0.950	<.001	<.001	3	2
GBM	CHRNA1 →	+1.119	+0.709	.008	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036491 vs RN7SL592P — CCRCC

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