Regulation of translation initiation in response to endoplasmic reticulum stress

Across TCGA cell cohorts, RNA activity of the Regulation of translation initiation in response to endoplasmic reticulum stress pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ACY1, SASS6, and DDIAS, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ACY1 grouped by Regulation of translation initiation in response to endoplasmic reticulum stress-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	ACY1 →	-0.836	-0.673	.008	.008	3	4
STOMACH	SASS6 →	+0.726	+0.932	<.001	.003	3	3
UPPER_AERODIGESTIVE_TRACT	DDIAS →	+2.182	+0.347	.004	.003	3	3
STOMACH	DEPDC4 →	+0.438	+0.813	<.001	<.001	3	3
STOMACH	DGKG →	+1.433	+0.679	.002	.008	3	3
STOMACH	IDI1 →	+1.075	+0.712	.004	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ACY1 by Regulation of translation initiation in response to endoplasmic reticulum stress activity — STOMACH

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