Regulation of translation initiation in response to endoplasmic reticulum stress

Across TCGA cell cohorts, RNA activity of the Regulation of translation initiation in response to endoplasmic reticulum stress pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DNAJC3, GPR89B, and GOLPH3L, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of translation initiation in response to endoplasmic reticulum stress activity versus DNAJC3 in LUNG_SCLC (Pearson r = 0.69).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	DNAJC3 →	+1.413	+0.943	<.001	<.001	3	6
BLOOD_Lymphoma	GPR89B →	+1.078	+1.269	.008	.001	3	4
BLOOD_Lymphoma	GOLPH3L →	+0.759	+1.460	.001	<.001	3	4
BLOOD_Lymphoma	TGDS →	+1.113	+1.148	.002	.003	3	4
OVARY	ID3 →	-3.590	-1.393	.004	<.001	3	4
LARGE_INTESTINE	NDFIP2 →	+0.718	+0.998	.005	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036491 vs DNAJC3 — LUNG_SCLC

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