Regulation of translation in response to endoplasmic reticulum stress

Across TCGA patient cohorts, RNA activity of the Regulation of translation in response to endoplasmic reticulum stress pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are OXCT2P1, KLB, and SUSD5, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of translation in response to endoplasmic reticulum stress activity versus OXCT2P1 in GBM (Pearson r = -0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	OXCT2P1 →	-0.281	-0.250	.004	.006	3	4
PDAC	KLB →	+0.366	+0.104	.001	.001	3	4
LSCC	SUSD5 →	-0.501	-0.682	.006	.002	3	4
GBM	APBB1 →	-0.407	-0.307	.007	.001	3	4
HNSC	SEPTIN4 →	-0.369	-0.187	.009	.005	3	4
COAD	SMAD7 →	-0.403	-0.165	.004	.005	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036490 vs OXCT2P1 — GBM

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