Regulation of translation in response to endoplasmic reticulum stress

Across TCGA cell cohorts, RNA activity of the Regulation of translation in response to endoplasmic reticulum stress pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DNAJC3, STK24, and SNTA1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of translation in response to endoplasmic reticulum stress activity versus DNAJC3 in LARGE_INTESTINE (Pearson r = 0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	DNAJC3 →	+0.882	+0.176	<.001	.001	3	6
LUNG_NSCLC_LUAD	STK24 →	+0.984	+0.219	.005	.002	3	5
LUNG_NSCLC_LUSC	SNTA1 →	-2.173	-0.205	<.001	.006	3	5
URINARY_TRACT	GMDS →	+1.279	+0.316	.002	.006	3	5
LARGE_INTESTINE	TDRD3 →	+0.834	+0.226	<.001	<.001	3	5
BLOOD_Myeloma	STAT4 →	-2.719	-0.255	.003	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036490 vs DNAJC3 — LARGE_INTESTINE

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