Intrinsic apoptotic signaling pathway in response to hydrogen peroxide

Across TCGA patient cohorts, RNA activity of the Intrinsic apoptotic signaling pathway in response to hydrogen peroxide pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RN7SL455P, C19orf44, and SNX30, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Intrinsic apoptotic signaling pathway in response to hydrogen peroxide activity versus RN7SL455P in LSCC (Pearson r = -0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RN7SL455P →	-0.500	-0.130	<.001	<.001	3	4
UCEC	C19orf44 →	-0.562	-0.091	.003	.005	3	3
GBM	SNX30 →	+0.518	+0.173	<.001	<.001	3	3
GBM	EIF4E3 →	+0.374	+0.146	.006	.002	3	3
GBM	C1QL3 →	+1.343	+0.163	<.001	.001	3	3
GBM	FAM86B3P →	-0.361	-0.138	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036481 vs RN7SL455P — LSCC

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