Intrinsic apoptotic signaling pathway in response to hydrogen peroxide

Across TCGA patient cohorts, RNA activity of the Intrinsic apoptotic signaling pathway in response to hydrogen peroxide pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MAP2K4, CAMSAP3_S814, and CBX3_S176, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Intrinsic apoptotic signaling pathway in response to hydrogen peroxide activity versus MAP2K4 in GBM (Pearson r = 0.43).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	MAP2K4 →	+0.374	+0.172	<.001	<.001	3	4
GBM	CAMSAP3_S814 →	+0.554	+0.141	<.001	<.001	3	3
GBM	CBX3_S176 →	-0.720	-0.197	<.001	<.001	3	3
GBM	RUFY2 →	+0.314	+0.215	<.001	<.001	3	3
GBM	USP43_S818 →	+1.743	+0.463	<.001	<.001	3	3
GBM	WDR43_S77 →	-0.467	-0.165	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036481 vs MAP2K4 — GBM

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