Synaptic vesicle recycling via endosome

Across TCGA cell cohorts, RNA activity of the Synaptic vesicle recycling via endosome pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are REXO2, DSE, and CEACAM5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, REXO2 grouped by Synaptic vesicle recycling via endosome-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	REXO2 →	-1.071	-1.118	.002	.001	3	5
LUNG_NSCLC_LUSC	DSE →	-1.621	-1.337	.004	.007	3	5
LARGE_INTESTINE	CEACAM5 →	+3.172	+0.985	.002	.001	3	5
BREAST	AIF1L →	+1.616	+0.918	.002	<.001	3	4
OVARY	CLDN11 →	-2.949	-1.399	.002	<.001	3	4
BREAST	TPP1 →	-0.808	-0.857	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

REXO2 by Synaptic vesicle recycling via endosome activity — OVARY

Explore this box plot interactively →