Synaptic vesicle recycling

Across TCGA patient cohorts, RNA activity of the Synaptic vesicle recycling pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TRIM3_S7, CMSS1, and ITSN1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Synaptic vesicle recycling activity versus TRIM3_S7 in BRCA (Pearson r = 0.28).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TRIM3_S7 →	+0.693	+0.029	.001	<.001	3	6
BRCA	CMSS1 →	-0.538	-0.023	<.001	.001	3	6
BRCA	ITSN1 →	+0.318	+0.027	<.001	<.001	3	6
GBM	RPL6 →	-0.635	-0.108	<.001	<.001	3	6
HNSC	MPRIP →	+0.234	+0.032	<.001	.002	3	6
GBM	RPL4 →	-0.435	-0.114	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036465 vs TRIM3_S7 — BRCA

Explore this scatter interactively →