Synaptic vesicle recycling

Across TCGA patient cohorts, RNA activity of the Synaptic vesicle recycling pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MYBL2, TPX2, and DDIAS, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Synaptic vesicle recycling activity versus MYBL2 in LUAD (Pearson r = -0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	MYBL2 →	-1.219	-0.173	<.001	<.001	3	6
LUAD	TPX2 →	-0.992	-0.154	<.001	<.001	3	6
BRCA	DDIAS →	-0.600	-0.120	.003	.005	3	6
LUAD	KIF4A →	-0.828	-0.148	.007	<.001	3	5
LUAD	KIF14 →	-0.744	-0.106	.004	.002	3	5
LUAD	DLGAP5 →	-0.968	-0.132	.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036465 vs MYBL2 — LUAD

Explore this scatter interactively →