Synaptic vesicle recycling

Across TCGA cell cohorts, RNA activity of the Synaptic vesicle recycling pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAP4, TNFRSF9, and GPR68, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MAP4 grouped by Synaptic vesicle recycling-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	MAP4 →	-0.655	-0.832	.004	.003	3	4
UPPER_AERODIGESTIVE_TRACT	TNFRSF9 →	-1.246	-0.366	.001	.003	3	4
BLOOD_Leukemia	GPR68 →	-0.931	-0.229	.001	<.001	3	4
BLOOD_Leukemia	TNFRSF10B →	-2.248	-0.236	.005	.001	3	4
BLOOD_Leukemia	CHEK2 →	+0.689	+0.220	.003	.003	3	4
SOFT_TISSUE	MYO5A →	-1.393	-0.770	<.001	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MAP4 by Synaptic vesicle recycling activity — OESOPHAGUS

Explore this box plot interactively →