TRAIL-activated apoptotic signaling pathway

Across TCGA patient cohorts, RNA activity of the TRAIL-activated apoptotic signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SP100_S171, IFI16, and DNAJC13, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, TRAIL-activated apoptotic signaling pathway activity versus SP100_S171 in LSCC (Pearson r = 0.41).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SP100_S171 →	+0.602	+0.060	<.001	.001	3	8
GBM	IFI16 →	+0.458	+0.073	<.001	<.001	3	8
GBM	DNAJC13 →	+0.228	+0.092	<.001	<.001	3	8
GBM	ICAM1 →	+0.643	+0.063	<.001	<.001	3	8
GBM	MSN →	+0.444	+0.099	<.001	<.001	3	8
GBM	DPYD →	+0.857	+0.095	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036462 vs SP100_S171 — LSCC

Explore this scatter interactively →