TRAIL-activated apoptotic signaling pathway

Across TCGA patient cohorts, RNA activity of the TRAIL-activated apoptotic signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HNRNPK_S284, PTEN_T383, and ALDOB, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, TRAIL-activated apoptotic signaling pathway activity versus HNRNPK_S284 in LSCC (Pearson r = -0.07).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	HNRNPK_S284 →	-0.234	-0.176	<.001	.001	3	4
GBM	PTEN_T383 →	+0.620	+0.152	<.001	<.001	3	4
PDAC	ALDOB →	+0.827	+0.172	<.001	<.001	3	3
LSCC	ANAPC2_S534 →	+0.516	+0.320	<.001	<.001	3	3
GBM	KMT2B_S1032 →	+0.579	+0.235	<.001	<.001	3	3
CCRCC	DOCK9_S170 →	+0.702	+0.296	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036462 vs HNRNPK_S284 — LSCC

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