TRAIL-activated apoptotic signaling pathway

Across TCGA cell cohorts, RNA activity of the TRAIL-activated apoptotic signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AIFM2, CCDC43, and GINM1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, AIFM2 grouped by TRAIL-activated apoptotic signaling pathway-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	AIFM2 →	+1.115	+0.675	<.001	.002	3	4
KIDNEY	CCDC43 →	-0.244	-0.798	.008	.004	3	3
LUNG_NSCLC_LUSC	GINM1 →	+0.771	+1.337	.001	.002	3	3
OESOPHAGUS	BAG1 →	-1.574	-1.405	.002	<.001	3	3
BREAST	DEPP1 →	+1.845	+1.002	.002	.003	2	4
OESOPHAGUS	RAMAC →	-0.636	-0.884	.004	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

AIFM2 by TRAIL-activated apoptotic signaling pathway activity — BLOOD_Leukemia

Explore this box plot interactively →