TRAIL-activated apoptotic signaling pathway

Across TCGA cell cohorts, RNA activity of the TRAIL-activated apoptotic signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FADS3, SELPLG, and MTCL1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, TRAIL-activated apoptotic signaling pathway activity versus FADS3 in BLOOD_Leukemia (Pearson r = -0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	FADS3 →	-2.415	-0.354	<.001	<.001	3	5
BLOOD_Leukemia	SELPLG →	+3.265	+0.345	<.001	.001	3	4
BLOOD_Leukemia	MTCL1 →	-2.694	-0.340	<.001	.002	2	5
KIDNEY	DNAJC11 →	-1.240	-0.210	.001	.004	3	4
BLOOD_Lymphoma	SLC43A2 →	-2.334	-0.348	.001	.004	3	4
KIDNEY	PRDM4 →	-0.869	-0.210	<.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036462 vs FADS3 — BLOOD_Leukemia

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