Myofibroblast differentiation

Across TCGA patient cohorts, RNA activity of the Myofibroblast differentiation pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MIR3186, SYNJ1, and RAB37, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Myofibroblast differentiation activity versus MIR3186 in UCEC (Pearson r = 0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR3186 →	+0.819	+0.528	<.001	<.001	3	4
GBM	SYNJ1 →	-0.261	-0.645	.001	.001	3	3
CCRCC	RAB37 →	-0.507	-0.653	.001	.001	3	3
GBM	ITSN1 →	-0.295	-0.696	.009	.004	3	3
GBM	SEC14L6 →	-0.594	-0.742	.001	.002	3	3
GBM	MCM10 →	+0.545	+0.644	.003	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036446 vs MIR3186 — UCEC

Explore this scatter interactively →