Myofibroblast differentiation

Across TCGA patient cohorts, RNA activity of the Myofibroblast differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RB1, RB1_T356, and NAT10, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Myofibroblast differentiation activity versus RB1 in LSCC (Pearson r = -0.16).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RB1 →	+0.699	+0.454	<.001	<.001	3	7
LSCC	RB1_T356 →	+1.155	+0.320	<.001	.001	3	6
HNSC	NAT10 →	+0.325	+0.167	.001	.001	3	4
LSCC	RB1_S249 →	+0.917	+0.366	<.001	<.001	3	4
OV	RB1_S37 →	+1.654	+0.910	<.001	<.001	3	4
OV	RB1_T826 →	+1.491	+0.717	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036446 vs RB1 — LSCC

Explore this scatter interactively →