Myofibroblast differentiation

Across TCGA cell cohorts, RNA activity of the Myofibroblast differentiation pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TRPC1, R3HCC1, and FXR2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TRPC1 grouped by Myofibroblast differentiation-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	TRPC1 →	+2.317	+2.086	.001	<.001	3	4
BLOOD_Leukemia	R3HCC1 →	+0.617	+0.772	.004	.007	3	4
URINARY_TRACT	FXR2 →	+0.977	+2.035	.002	<.001	3	3
STOMACH	CTSV →	-1.410	-1.391	.001	<.001	3	3
LARGE_INTESTINE	DECR1 →	+1.203	+1.263	<.001	.001	3	3
LARGE_INTESTINE	GABARAP →	+0.734	+1.038	<.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TRPC1 by Myofibroblast differentiation activity — URINARY_TRACT

Explore this box plot interactively →