Myofibroblast differentiation

Across TCGA cell cohorts, RNA activity of the Myofibroblast differentiation pathway is significantly associated with the drug response of multiple features, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated features across cancer lineages are PD173074, Axitinib, and Staurosporine, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PD173074 grouped by Myofibroblast differentiation-low versus -high activity in CNS.

Pathway-associated features by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner feature	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	PD173074 →	+0.754	+0.595	.003	.013	3	2
CNS	Axitinib →	+1.012	+0.595	.006	.013	3	1
CNS	Staurosporine →	+0.739	+0.595	.005	.013	3	1
CNS	MCT1_6447 →	+0.343	+0.543	.032	.032	3	1
CNS	Foretinib →	+0.547	+0.682	.007	.007	2	2
CNS	Belinostat →	-1.054	-1.085	.048	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PD173074 by Myofibroblast differentiation activity — CNS

Explore this box plot interactively →