Sodium ion export across plasma membrane

Across TCGA cell cohorts, RNA activity of the Sodium ion export across plasma membrane pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC26A3, XKR9, and DZIP1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SLC26A3 grouped by Sodium ion export across plasma membrane-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	SLC26A3 →	+0.032	+0.829	.009	.004	3	4
LARGE_INTESTINE	XKR9 →	+1.138	+0.782	<.001	.001	3	3
LUNG_NSCLC_LUAD	DZIP1 →	-1.648	-0.455	.001	.005	3	3
LUNG_NSCLC_LUAD	GJA1 →	-2.066	-0.382	.002	.007	3	3
LARGE_INTESTINE	ZNF92 →	+0.443	+0.649	.003	.001	3	3
SKIN	ZACN →	-0.693	-1.002	.003	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SLC26A3 by Sodium ion export across plasma membrane activity — CNS

Explore this box plot interactively →