Sodium ion export across plasma membrane

Across TCGA cell cohorts, RNA activity of the Sodium ion export across plasma membrane pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ATP1A1, GPCPD1, and IFITM1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sodium ion export across plasma membrane activity versus ATP1A1 in SOFT_TISSUE (Pearson r = 0.66).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	ATP1A1 →	+1.282	+0.438	.009	.001	2	7
BREAST	GPCPD1 →	+0.743	+0.222	.006	.004	3	5
OVARY	IFITM1 →	+4.346	+0.240	<.001	<.001	3	5
BREAST	PLSCR1 →	+2.663	+0.316	<.001	.005	3	5
BREAST	ANKRD34A →	-0.945	-0.358	<.001	.001	3	5
UPPER_AERODIGESTIVE_TRACT	CEP112 →	-1.232	-0.382	.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036376 vs ATP1A1 — SOFT_TISSUE

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