Psychomotor behavior

Across TCGA patient cohorts, RNA activity of the Psychomotor behavior pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NUP37, GDF10, and NALCN, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Psychomotor behavior activity versus NUP37 in LSCC (Pearson r = 0.04).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	NUP37 →	-0.381	-0.408	<.001	<.001	3	4
PDAC	GDF10 →	+0.292	+0.155	<.001	<.001	3	4
GBM	NALCN →	+0.933	+0.702	.001	<.001	3	3
GBM	HTR2A →	+1.023	+0.877	<.001	<.001	3	3
GBM	CAB39L →	+0.582	+0.589	<.001	.002	3	3
GBM	FGF9 →	+0.629	+0.526	.003	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036343 vs NUP37 — LSCC

Explore this scatter interactively →