Post-anal tail morphogenesis

pathway activity — cross-omics
GO:0036342Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Post-anal tail morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CRTAP, EFEMP2, and ISLR, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
OVCRTAP →+0.625+0.064<.001.00138
UCECEFEMP2 →+0.615+0.083<.001<.00138
PDACISLR →+0.659+0.063.001<.00138
OVP3H3 →+0.686+0.072.001<.00138
OVPCOLCE →+0.861+0.080.001<.00138
PDACCNN2 →+0.505+0.061<.001<.00138
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration