Dendritic cell migration

Across TCGA patient cohorts, RNA activity of the Dendritic cell migration pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CEP78, CD3G, and CD7, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Dendritic cell migration activity versus CEP78 in GBM (Pearson r = -0.22).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CEP78 →	-0.478	-0.278	<.001	<.001	3	5
LSCC	CD3G →	+0.707	+0.936	<.001	<.001	3	5
LSCC	CD7 →	+0.690	+0.748	<.001	<.001	3	5
GBM	HLA-DPB1 →	+1.094	+0.333	<.001	<.001	3	5
GBM	RPL32P1 →	+0.845	+0.260	<.001	<.001	3	5
GBM	HLA-DMB →	+0.827	+0.300	<.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036336 vs CEP78 — GBM

Explore this scatter interactively →