Dendritic cell migration

Across TCGA patient cohorts, RNA activity of the Dendritic cell migration pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DOCK8_S904, BIN2, and CIT, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Dendritic cell migration activity versus DOCK8_S904 in LSCC (Pearson r = 0.47).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	DOCK8_S904 →	+0.767	+0.955	<.001	<.001	3	4
GBM	BIN2 →	+0.622	+0.255	<.001	<.001	3	4
COAD	CIT →	-0.852	-0.299	.003	<.001	3	4
GBM	RCSD1 →	+0.467	+0.278	<.001	<.001	3	4
GBM	GRAP2 →	+0.596	+0.260	<.001	<.001	3	4
GBM	ARHGAP15 →	+0.591	+0.256	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036336 vs DOCK8_S904 — LSCC

Explore this scatter interactively →