Dendritic cell migration

Across TCGA cell cohorts, RNA activity of the Dendritic cell migration pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CROCC, GMFB, and INPP5A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CROCC grouped by Dendritic cell migration-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CROCC →	-0.869	-0.867	.002	.002	3	5
UPPER_AERODIGESTIVE_TRACT	GMFB →	-1.115	-1.201	.005	<.001	3	4
BLOOD_Myeloma	INPP5A →	-1.803	-1.760	.001	.001	3	4
BREAST	MGAT2 →	-0.786	-0.793	.005	.006	3	4
LUNG_NSCLC_LUSC	TTC1 →	-0.701	-0.976	.002	.001	3	4
LUNG_NSCLC_LUSC	WWC2 →	-1.293	-1.002	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CROCC by Dendritic cell migration activity — LARGE_INTESTINE

Explore this box plot interactively →