Dendritic cell migration

Across TCGA cell cohorts, RNA activity of the Dendritic cell migration pathway is significantly associated with the shRNA dependency of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are OTUD7A, SERPINA9, and TBX4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, OTUD7A grouped by Dendritic cell migration-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	OTUD7A →	+0.230	+0.171	.004	.001	3	4
SKIN	SERPINA9 →	+0.227	+0.164	<.001	<.001	3	4
STOMACH	TBX4 →	+0.150	+0.190	.009	.002	3	4
LUNG_NSCLC_LUAD	CXCL9 →	+0.148	+0.130	<.001	.003	3	4
BONE	ATCAY →	+0.427	+0.347	.006	.008	3	4
STOMACH	ACLY →	+0.358	+0.206	.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

OTUD7A by Dendritic cell migration activity — SKIN

Explore this box plot interactively →