Dendritic cell migration

Across TCGA cell cohorts, RNA activity of the Dendritic cell migration pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZADH2, MIEF2, and IL15, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Dendritic cell migration activity versus ZADH2 in SKIN (Pearson r = 0.67).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	ZADH2 →	+0.932	+0.175	.002	.002	3	4
LARGE_INTESTINE	MIEF2 →	-0.894	-0.199	<.001	<.001	3	4
CNS	IL15 →	-1.363	-0.123	.001	.006	3	4
CNS	IKZF2 →	-0.775	-0.184	.009	.003	3	4
BREAST	ARHGAP21 →	-0.917	-0.195	.003	.002	3	4
BREAST	GPD1L →	+1.873	+0.285	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036336 vs ZADH2 — SKIN

Explore this scatter interactively →