Intestinal stem cell homeostasis

Across TCGA cell cohorts, RNA activity of the Intestinal stem cell homeostasis pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PPP1R16A, RAG2, and APOB, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PPP1R16A grouped by Intestinal stem cell homeostasis-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	PPP1R16A →	+0.673	+0.786	.007	.007	3	4
OVARY	RAG2 →	+0.153	+1.466	.003	<.001	3	4
BREAST	APOB →	+0.027	+1.175	<.001	<.001	3	4
LUNG_NSCLC_LUAD	SHARPIN →	+0.530	+0.703	.009	.006	3	3
OESOPHAGUS	CRISPLD1 →	+2.444	+1.478	.001	.005	3	3
OVARY	MAP9 →	+1.522	+1.435	.003	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PPP1R16A by Intestinal stem cell homeostasis activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →