Vascular endothelial growth factor receptor-2 signaling pathway

Across TCGA patient cohorts, RNA activity of the Vascular endothelial growth factor receptor-2 signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the ESCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TEK, MYCT1, and PTPRB, each associated with the pathway in up to 33 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Vascular endothelial growth factor receptor-2 signaling pathway activity versus TEK in ESCA (Pearson r = 0.78).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	TEK →	+1.335	+0.121	<.001	<.001	3	33
TGCT	MYCT1 →	+2.377	+0.155	<.001	<.001	3	33
THYM	PTPRB →	+1.329	+0.124	<.001	<.001	3	33
MESO	DIPK2B →	+1.280	+0.093	<.001	<.001	3	33
SCLC	ROBO4 →	+1.326	+0.177	<.001	<.001	3	33
MESO	ADGRL4 →	+1.668	+0.094	<.001	<.001	3	33

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036324 vs TEK — ESCA

Explore this scatter interactively →