Vascular endothelial growth factor receptor-2 signaling pathway

Across TCGA patient cohorts, RNA activity of the Vascular endothelial growth factor receptor-2 signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ENG, CD34, and PLVAP, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Vascular endothelial growth factor receptor-2 signaling pathway activity versus ENG in CCRCC (Pearson r = 0.46).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	ENG →	+0.488	+0.076	<.001	<.001	3	7
BRCA	CD34 →	+0.835	+0.063	<.001	<.001	3	7
CCRCC	PLVAP →	+0.861	+0.079	<.001	<.001	3	7
UCEC	TNS2 →	+0.346	+0.057	<.001	.005	2	7
GBM	VWA1 →	+0.691	+0.095	<.001	<.001	3	6
BRCA	VWF →	+0.595	+0.070	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036324 vs ENG — CCRCC

Explore this scatter interactively →