Cellular response to sterol

Across TCGA patient cohorts, RNA activity of the Cellular response to sterol pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DNA2, TRAJ39, and BST2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to sterol activity versus DNA2 in BRCA (Pearson r = -0.21).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	DNA2 →	-0.521	-0.542	.002	.005	3	4
BRCA	TRAJ39 →	-0.623	-0.441	.001	.004	3	3
CCRCC	BST2 →	+0.394	+0.499	.004	.003	3	3
GBM	TAF5 →	-0.380	-0.657	<.001	.005	3	3
GBM	KNDC1 →	+0.736	+0.574	<.001	<.001	3	3
GBM	PLCXD2-AS1 →	-0.476	-0.871	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036315 vs DNA2 — BRCA

Explore this scatter interactively →