Cellular response to sterol

Across TCGA cell cohorts, RNA activity of the Cellular response to sterol pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are B3GNT5, PTMA, and GNG13, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, B3GNT5 grouped by Cellular response to sterol-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	B3GNT5 →	-1.298	-1.283	.008	.002	3	4
LUNG_SCLC	PTMA →	-0.768	-0.955	.001	.003	3	4
OVARY	GNG13 →	+0.359	+1.181	.005	.002	3	4
KIDNEY	SPOP →	-0.572	-1.539	.008	.001	3	3
KIDNEY	AHNAK2 →	-1.342	-1.118	.001	.004	3	3
OESOPHAGUS	DZIP3 →	+1.298	+1.588	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

B3GNT5 by Cellular response to sterol activity — OESOPHAGUS

Explore this box plot interactively →