Response to sterol

Across TCGA patient cohorts, RNA activity of the Response to sterol pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SEPTIN4_S325, SEPTIN4, and EFEMP1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to sterol activity versus SEPTIN4_S325 in LUAD (Pearson r = 0.22).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	SEPTIN4_S325 →	+0.550	+0.029	<.001	.004	3	8
LUAD	SEPTIN4 →	+0.339	+0.029	<.001	.002	3	7
COAD	EFEMP1 →	+0.720	+0.037	<.001	<.001	3	7
BRCA	GSTM3 →	+0.929	+0.033	<.001	<.001	3	7
CCRCC	NUMBL →	+0.356	+0.033	.004	.006	3	7
BRCA	TGFB1I1 →	+0.630	+0.041	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036314 vs SEPTIN4_S325 — LUAD

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