Response to sterol

Across TCGA patient cohorts, RNA activity of the Response to sterol pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GPSM2, NSMCE4A, and IL15RA, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to sterol activity versus GPSM2 in LSCC (Pearson r = -0.13).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	GPSM2 →	-0.486	-0.475	.005	.001	3	4
LSCC	NSMCE4A →	-0.299	-0.266	.003	.008	3	3
UCEC	IL15RA →	+0.614	+0.406	.002	.007	3	3
UCEC	DACT3 →	+0.639	+0.432	.001	.008	2	4
GBM	PLA2G5 →	+0.816	+0.521	.003	.001	3	3
GBM	RPS27AP16 →	-0.248	-0.537	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036314 vs GPSM2 — LSCC

Explore this scatter interactively →