Response to sterol

Across TCGA cell cohorts, RNA activity of the Response to sterol pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FAM151B, CEBPA, and CRTC3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to sterol activity versus FAM151B in BLOOD_Leukemia (Pearson r = 0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	FAM151B →	+0.641	+0.804	.005	.003	3	4
BLOOD_Leukemia	CEBPA →	+3.783	+0.971	.001	.004	3	4
LUNG_NSCLC_LUSC	CRTC3 →	+1.188	+1.433	<.001	<.001	3	4
LUNG_NSCLC_LUAD	CPE →	+2.823	+0.857	.001	.002	3	4
OVARY	ID3 →	+2.543	+1.584	<.001	<.001	3	4
OESOPHAGUS	GSTA4 →	+1.954	+1.073	.002	.002	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036314 vs FAM151B — BLOOD_Leukemia

Explore this scatter interactively →