Ameloblast differentiation

Across TCGA patient cohorts, RNA activity of the Ameloblast differentiation pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC25A30-AS1, SRRD, and TXN2, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ameloblast differentiation activity versus SLC25A30-AS1 in LSCC (Pearson r = -0.12).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SLC25A30-AS1 →	-0.183	-0.284	.007	.008	3	2
LSCC	SRRD →	+0.261	+0.295	.008	.006	3	1
LSCC	TXN2 →	+0.386	+0.258	<.001	.008	3	1
LSCC	UPK3A →	-0.382	-0.253	<.001	.002	3	1
LSCC	NDRG1 →	+1.581	+0.361	<.001	<.001	3	1
LSCC	COL7A1 →	+1.666	+0.346	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036305 vs SLC25A30-AS1 — LSCC

Explore this scatter interactively →