Lymph vessel morphogenesis

Across TCGA patient cohorts, RNA activity of the Lymph vessel morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MSRB3, MFGE8, and ZEB1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lymph vessel morphogenesis activity versus MSRB3 in UCEC (Pearson r = 0.15).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MSRB3 →	+1.098	+0.421	<.001	.001	3	5
LSCC	MFGE8 →	+0.544	+0.194	.001	<.001	2	5
UCEC	ZEB1 →	+0.802	+0.306	<.001	.002	2	5
OV	PTPN14 →	+1.164	+0.665	<.001	.003	3	4
BRCA	FAM180A →	+1.159	+0.551	<.001	.003	3	4
GBM	ADAMTS9-AS1 →	+0.628	+0.622	.009	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036303 vs MSRB3 — UCEC

Explore this scatter interactively →